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A groundbreaking discovery has recently revealed a unique gene linked to human brain development — laminin gamma 3 (LAMC3). This gene plays a crucial role in shaping the cerebral cortex, the outer layer of the brain responsible for complex thinking, emotions, and memory. The research, conducted by scientists from Yale University and institutions in Turkey, was inspired by a patient with unusually smooth brain folds, offering new insights into how these structures form. The cerebral cortex is known for its intricate folds, which significantly increase the surface area of the brain, allowing for advanced cognitive functions. These folds are most prominent in humans and other large-brained animals like dolphins and marmosets. However, the exact mechanism behind their formation has long remained a mystery. This study suggests that LAMC3 may be the key to unlocking this process. Researchers found that LAMC3 is active during the embryonic stage, when critical neural connections are formed. While the gene is also present in species with flat brains, such as mice, it appears to have evolved uniquely in humans, enabling the development of the occipital cortex and distinguishing our brains from those of other animals. This discovery could revolutionize neuroscience, particularly for projects like the "Human Brain Project," which aims to create a detailed computer model of the human brain. With a budget of £1 billion, the project seeks to simulate brain activity and potentially offer breakthroughs in treating neurological disorders like Parkinson’s disease. So far, scientists have successfully modeled the activity of around 10,000 neurons — equivalent to a single mouse's new cortical unit. These units are essential for rational thought and are believed to be a key component of human cognition. As research progresses, the understanding of genes like LAMC3 may bring us closer to creating artificial brains that can mimic human intelligence and help solve some of the greatest mysteries of the mind.

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July 20, 2025