Intel Nuc I3,I3 Mini Pc,Intel Nuc 11 I3,Mini Pc Intel I3 Guangdong Elieken Electronic Technology Co.,Ltd. , https://www.elieken.com
Recently, Wu Yihui, a researcher at the State Key Laboratory of Applied Optics, Chinese Academy of Sciences' Changchun Institute of Optics, Fine Mechanics and Physics, introduced an innovative ultra-high sensitivity biosensor based on fiber-optic mode coupling. This non-standard biosensor leverages the unique properties of fiber couplers to detect biomarkers, such as those related to cancer, with remarkable precision.
Acute myocardial infarction (AMI) is a life-threatening condition that requires rapid diagnosis and accurate risk assessment to reduce mortality. Cardiac troponin I (cTnI) is considered the gold standard for AMI detection due to its high specificity and sensitivity. However, cTnI levels in the blood are extremely low during the early stages of AMI, making early detection challenging and demanding highly sensitive tools.
Building upon previous research on optical fiber biosensors, Wu's team developed a novel biosensor using a fiber coupler structure. The sensor exploits interference between odd and even modes within the fiber coupler. At the turning point, where refractive indices are equal, the system exhibits zero dispersion, theoretically leading to infinite sensitivity. In experiments, the refractive index sensitivity reached 91,777.9 nm/RIU, while the detection limit for cTnI was as low as 2 fg/mL—setting a new benchmark in the field.
This breakthrough demonstrates not only exceptional sensitivity but also strong specificity and reproducibility, which are crucial for real-world biosensor applications. The study was published in *Biosensors and Bioelectronics* and supported by several key funding projects, including the China-Israel International Science and Technology Cooperation Program and the National Natural Science Foundation.
The research includes detailed figures showing the sensor design, theoretical calculations, and experimental results. These visualizations highlight the performance of the biosensor under various conditions, demonstrating its potential for future medical diagnostics.
Paper link
Figure 1: (a) Schematic diagram of the fiber coupler sensor, (b) Theoretically calculated sensitivity versus wavelength for different fiber diameters near the turning point.
Figure 2: (a) Spectral curves for different concentrations of cTnI around the turning point, (b) Peak concentration shifts, (c) Real-time dynamic responses at 2fg/mL and 4fg/mL, (d) Specificity comparison with non-specific proteins.
September 26, 2025